袁谷
發(fā)布時間:2011-04-10 閱讀次數(shù)：10163次
袁 谷 教授
化學(xué)生物學(xué), 化學(xué)生物質(zhì)譜學(xué)，有機合成
北京大學(xué)化學(xué)與分子工程學(xué)院化學(xué)生物學(xué)系教授、博士生導(dǎo)師
1992年在日本高知大學(xué)獲博士學(xué)位，1992年7月- 1994年6月在北京大學(xué)化學(xué)博士后流動站進行博士后研究工作?，F(xiàn)任北京大學(xué)化學(xué)院化學(xué)生物學(xué)系教授、博士生導(dǎo)師、北京大學(xué)化學(xué)院學(xué)位委員會委員、生物有機與分子工程教育部重點實驗室副主任、北京市化學(xué)會理事， 中國化學(xué)會化學(xué)生物學(xué)專業(yè)委員會委員。在DNA識別和切割及生物有機質(zhì)譜學(xué)領(lǐng)域取得了一系列研究成果，在國內(nèi)外著名學(xué)術(shù)刊物上發(fā)表論文70余篇。其相似分析-質(zhì)譜法鑒定昆蟲性信息素的雙鍵位置及質(zhì)譜的研究，獲1995年度國家教委科學(xué)技術(shù)進步三等獎(項目主持人)；昆蟲性信息素及類似物質(zhì)譜測定的研究，獲中國分析測試協(xié)會1994年度二等獎(項目參加者)；1996年獲中國博士后科學(xué)基金會"國氏"博士后獎勵基金。
主要研究領(lǐng)域DNA識別分子的研究，生物有機質(zhì)譜學(xué)的研究，近年主要研究成果包括：建立了溶液法合成寡聚酰胺的新方法；合成了一系列對HIV-1基因具有高親和力的新型DNA識別分子；發(fā)展了ESI 質(zhì)譜法研究小分子與DNA非共價結(jié)合的方法。
主講課程:
1.有機化合物的結(jié)構(gòu)鑒定(本科生) 2.表征技術(shù)-波譜學(xué)(研究生)
研究領(lǐng)域和興趣:
1.DNA識別分子的合成及活性研究 2.化學(xué)生物質(zhì)譜學(xué)
代表性發(fā)表文章Selected Publications
1. Li HH, Zhou J, Tang FL, Yuan G*, Investigation of noncovalent complexes between beta-cyclodextrin and polyamide acids containing N-methylpyrrole and N-methylimidazole by electrospray ionization mass spectrometry,Journal of the American Society for Mass Spectrometry, 17 (1), 9-14, 2006.
2. Li HH, Yuan G*, Electrospray ionization mass spectral characteristics and fragmentation mechanisms of Angiotensin II and its analogues,International Journal of Mass Spectrom, 252 (1): 54-60, 2006.
3. Li HH, Yuan G*, Investigation of non-covalent complexes of HIV-1 promoter DNA and polyamides containing N-methylpyrrole by electrospray ionization mass spectrometry,Rapid Commun. Mass Spectrom., 20 (11): 1736-1740, 2006.
4. Liu D, Yuan G*, Hu JM, Synthesis and photo-induced DNA cleaving activities of conjugates of halophenyl derivative and polyamide containing N-methylimidazoles,Journal of Photochem Photobiology B-Biology, 82 (3): 187-193, 2006.
5. Wang J, Yuan G*, Synthesis of homoallylic alcohols from ketones in water,Synthetic Communications,36 (3): 401-405 2006.
6. Zhou J, Yuan G*, Analysis of noncovalent complexes between human telomeric DNA and polyamides containing N-methylpyrrole and N-methylimidazole by using electrospray ionization mass spectrometry,Chemistry -A European Journal, 11: 1157, 2005.
7. Wang J, Miao XP, Yuan G*, Selective carbonyl propargylation mediated by SnCl2/NiCl2-KI in water Australian Journal of Chemistry, 58 (8): 611-614, 2005.
8. Wang J, Zhou J, Yuan G*, Electrospray negative ionization mass spectrometry of polyamides containing N-methylpyrrole and N-methylimidazole,Journal of Mass Spectrom. 40: 688, 2005.
9. Liu Dan, Zhou Jiang, Yuan G*, Electrospray ionization mass spectral characteristics and fragmentation mechanisms of novel photoinduced DNA-cleaving agents formed as conjugates of haloarenes and polyamides containing N-methylimidazole,Rapid Commun. Mass Spectrom., 18: 2770, 2004.
10. Zhou J, Yuan G*, Electrospray ionization mass spectrometric analysis of noncovalent complexes between DNA and …, Rapid Commun. Mass Spectrom. 18, 1519, 2004.
11. Yuan G*, Zhou J, Electrospray ionization mass spectral fragmentation mechanisms of DNA-recognizing …, Rapid Commun. Mass Spectrom. 18, 1397, 2004.
12. Wang J, Yuan G*, et al., Novel ultrasonication-assisted carbonyl allylation mediated by SnCl2 in water, Chemistry Letters , 33 (3), 286, 2004.
13. Zhu C.G., Yang X.L., Cao S.X., Yuan G, et al., Monitoring the synthetic reaction of a polyamide/peptide ,…, Rapid Commun. Mass Spectrom.,17, 825 (2003).
14. Tang F.L., Yuan G*, Wang J, Synthesis and photoinduced DNA cleaving activity of hairpin polyamide-chlorobenzenesulfonyl conjugate, Photochem. Photobiol. 78, 175 (2003).
15. Yuan G*, Tang F.L., Synthesis of DNA-recognizing polyamides containing N-methylpyrrole and N-methylimidazole, Arkivoc, 32, (2003).
16. Yuan G*, et al, Fragmentation mechanisms of polyamides containing N-methylpyrrole and N-methylimidazole by electrospray ionization tandem mass spectrometry, Rapid Commun. Mass Spectrom. 17, 2015( 2003).
17. Yuan G*, Xiao J.H., et al, Synthesis of polyamides containing N-methylpyrrole and N-methylimidazole and their anticancer activity,Archives of Pharmacal Research, 25, 585(2002).
18. Tang F.L., Wang J., Liu D., Yuan G*, et al, Electrospray ionization tandem mass spectrometric characteristics and fragmentation mechanisms of distamycin analogues, Rapid Commun. Mass Spectrom.,16，1035( 2002).
19. Yuan G*, Yan J.C., A formula for calculation of double bond position of tetradecenols based on mass spectra of dimethyl disulfide derivatives, Rapid Commun. Mass Spectrom.,16, 11 (2002).
20. Xiao J.H., Yuan G*, et al, A convenient method for the synthesis of DNA-recognizing polyamides in solution, J. Org. Chem., 65, 5506 ( 2000).
21. Yuan G*, He M.Y., Wang G. J., Wang Q. B., Electron impact mass spectral characteristics and fragmentation pathways of isomeric tetradecadien-1-ols, Rapid Commun.Mass Spectrom., 13, 1 (1999).
22. Yuan G*, Xiao J.H., et al, Similarity between mass spectra of isomeric alkenols and their acetates, Rapid Commun. Mass Spectrom., 12, 1287(1998).
23. Yuan G*, et al, Similarity between mass spectra of double-bond positional isomers of tetradecen-1-ols and their acetates, Rapid Commun. Mass Spectrom., 11, 1699 (1997).
24. Yuan G*, Identification of the configuration of sex pheromones with a conjugated double bond by fuzzy similarity analysis of chemical shifts of olefinic carbons, Fresenius J. Anal. Chem., 354, 241(1996).